In Vitro Drug Release, Permeability, and Structural Test of Ciprofloxacin-Loaded Nanofibers

Nanofibers of the poorly water-soluble antibiotic ciprofloxacin (CIP) were fabricated in form an amorphous solid dispersion by using poly(vinyl pyrrolidone) as a polymer matrix, low-cost electrospinning method. The solubility nanofibers well their vitro diffusion remarkably higher than those CIP powder or physical mixture two components. fiber size and morphology optimized, it was found that addition to solution decreased nanofiber diameter, leading increased specific surface area. Structural characterization confirmed interactions between drug state inside nanofibers. Since is pH-dependent, dissolution studies executed at different pH levels. sample with finest demonstrated significant increase both water 7.4 buffer. Single medium two-stage biorelevant performed, release mechanism described mathematical models. Besides, from 6.8 notably when compared pure mixture. Ciprofloxacin-loaded (PVP) can be considered fast-dissolving formulations improved physicochemical properties.